Leslie Charleson -- who played Monica Quartermaine on the soap opera General Hospital for decades -- has died at the age of 79.

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Variety said she died Sunday after a long, unspecified illness.

"It is with a heavy heart that I announce the passing of our dead friend and colleague Leslie Charleson," the daytime drama's executive producer said in a statement on Instagram.

"Her enduring legacy has spanned nearly 50 years on General Hospital alone, and just as Monica was the heart of the Quartermaines, Leslie was a beloved matriarch of the entire cast and crew."

The Kansas City native also appeared in A Flame in the Wind, Love is a Many Splendored Thing, The Rockford Files, The Wild West, The Streets of San Francisco,Marcus Welby, M.D., Mannix, Ironside, Happy Days and The Day of the Dolphin.