"I Am Cait's" second season will include Caitlyn Jenner confronting protesters, trying on wedding dresses and meeting presidential hopeful Hillary Clinton.
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"I don't wanna hurt anybody," she said.
"Don't you mean you don't want to get hurt yourself?" the friend responds.
The clip shows protesters picketing around Jenner as she leaves a downtown venue, with one telling the celebrity through a loudspeaker she is "an insult to trans people."
"I'm slowly coming into my womanhood, but it's a work in progress," Jenner is heard saying over the clip. "I need to evolve as a person. There's just too much at stake to get it wrong."Season 2 of "I Am Cait" will premiere March 6 on E!.