Taylor Tomlinson's talk-show, After Midnight, is ending after two seasons.
CBS does not plan to fill the time slot with original programming after that.
"Hosting After Midnight has genuinely been the experience of a lifetime, and I'll be forever grateful for the opportunity to be part of this incredible journey," Tomlinson said in a statement Wednesday.
"Though it was an extremely tough decision, I knew I had to return to my first passion and return to stand-up touring full-time," she added. "I appreciate CBS, Stephen Colbert, the producers, and the entire After Midnight staff and crew for all the love, support, and unforgettable memories."